Dennis N Bourdette Selected Research

Thioctic Acid (Lipoic Acid)

4/2019	Oral lipoic acid as a treatment for acute optic neuritis: a blinded, placebo controlled randomized trial.
12/2018	Effects of lipoic acid on walking performance, gait, and balance in secondary progressive multiple sclerosis.
7/2011	Lipoic acid stimulates cAMP production via G protein-coupled receptor-dependent and -independent mechanisms.
9/2010	Lipoic acid attenuates inflammation via cAMP and protein kinase A signaling.
4/2010	Pharmacokinetic study of lipoic acid in multiple sclerosis: comparing mice and human pharmacokinetic parameters.
8/2008	Lipoic acid stimulates cAMP production via the EP2 and EP4 prostanoid receptors and inhibits IFN gamma synthesis and cellular cytotoxicity in NK cells.
6/2008	Lipoic acid: a novel therapeutic approach for multiple sclerosis and other chronic inflammatory diseases of the CNS.
6/2006	Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56(Lck).
6/2006	Lipoic acid inhibits expression of ICAM-1 and VCAM-1 by CNS endothelial cells and T cell migration into the spinal cord in experimental autoimmune encephalomyelitis.
11/2004	Alpha lipoic acid inhibits human T-cell migration: implications for multiple sclerosis.

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Dennis N Bourdette Research Topics

Disease

27	Multiple Sclerosis 03/2022 - 07/2003
14	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 04/2010 - 10/2002
4	Inflammation (Inflammations) 09/2010 - 09/2003
3	Demyelinating Diseases (Demyelinating Disease) 01/2021 - 08/2004
2	Optic Neuritis (Retrobulbar Neuritis) 02/2022 - 04/2019
2	Nephrotic Syndrome (Syndrome, Nephrotic) 02/2022 - 01/2019
2	Encephalomyelitis (Myeloencephalitis) 04/2019 - 02/2010
2	Cognitive Dysfunction 10/2011 - 01/2006
2	Diabetic Neuropathies (Diabetic Neuropathy) 07/2011 - 06/2008
2	Alzheimer Disease (Alzheimer's Disease) 07/2011 - 06/2008
1	Infantile Spasms (West Syndrome) 02/2022
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 02/2022
1	Rheumatoid Arthritis 02/2022
1	Ankylosing Spondylitis 02/2022
1	Ganglion Cysts (Ganglion) 01/2019
1	Atrophy 01/2019
1	Chronic Progressive Multiple Sclerosis 12/2018
1	Glioblastoma (Glioblastoma Multiforme) 06/2015
1	Vasculitis (Vasculitides) 06/2014
1	Spinal Cord Diseases 06/2014
1	Nervous System Diseases (Neurological Disorders) 02/2010
1	Myasthenia Gravis 02/2010
1	Critical Illness (Critically Ill) 02/2010
1	Autoimmune Diseases (Autoimmune Disease) 01/2008
1	Thymoma (Thymic Carcinoma) 09/2004
1	Disease Progression 08/2004

Drug/Important Bio-Agent (IBA)

11	Thioctic Acid (Lipoic Acid)IBA 04/2019 - 10/2002
7	AntioxidantsIBA 04/2019 - 10/2002
6	Peptides (Polypeptides)IBA 01/2008 - 09/2003
5	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2012 - 09/2003
4	LigandsIBA 01/2012 - 04/2004
2	Adrenocorticotropic Hormone (ACTH)FDA Link 02/2022 - 01/2019
2	Adrenal Cortex Hormones (Corticosteroids)IBA 02/2022 - 02/2010
2	Retinaldehyde (Retinal)IBA 04/2019 - 01/2019
2	AntigensIBA 09/2006 - 01/2005
2	myelin proteolipid protein (139-151)IBA 09/2006 - 08/2004
1	Prescription DrugsIBA 03/2022
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	Glatiramer Acetate (Copaxone)FDA Link 01/2020
1	GlucocorticoidsIBA 01/2019
1	GadoliniumIBA 02/2016
1	Contrast MediaIBA 06/2015
1	Minocycline (Cyclops)FDA LinkGeneric 06/2014
1	Fatty Acids (Saturated Fatty Acids)IBA 07/2011
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 09/2010
1	Intravenous Immunoglobulins (IVIG)FDA Link 02/2010
1	Protein Subunit VaccinesIBA 01/2008
1	LipopolysaccharidesIBA 01/2007
1	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA 06/2006
1	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 06/2006
1	propylene diquat (PDQ(+))IBA 01/2006
1	HLA-DR2 Antigen (HLA DR2 Antigen)IBA 09/2004
1	alpha-beta T-Cell Antigen Receptors (T-Cell Receptor alpha-Chain)IBA 09/2004
1	HLA-DRB1 Chains (HLA DRB1)IBA 09/2004
1	Myelin-Oligodendrocyte GlycoproteinIBA 09/2004
1	Freund's AdjuvantIBA 08/2004
1	Immunosuppressive Agents (Immunosuppressants)IBA 08/2004
1	Tacrolimus (Prograf)FDA LinkGeneric 08/2004
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 08/2004
1	FK1706IBA 08/2004
1	CytokinesIBA 04/2004
1	alpha-Crystallin B ChainIBA 02/2004
1	ChemokinesIBA 09/2003
1	Cytokine Receptors (Cytokine Receptor)IBA 09/2003
1	Complement System Proteins (Complement)IBA 09/2003
1	Myelin Basic ProteinIBA 09/2003
1	Gonadal Steroid Hormones (Sex Hormones)IBA 07/2003

Therapy/Procedure

10	Therapeutics 08/2021 - 04/2004
1	Critical Care (Surgical Intensive Care) 02/2010
1	Plasmapheresis 02/2010
1	Immunomodulation 02/2010